美國(guó)化學(xué)學(xué)會(huì)的藥物化學(xué)信件有興趣收到手稿，討論藥物化學(xué)的各個(gè)方面。該雜志將發(fā)表涉及廣泛主題的研究，包括化合物設(shè)計(jì)和優(yōu)化、生物評(píng)價(jià)、藥物傳遞、顯像劑以及小分子和大分子生物活性分子的藥理學(xué)。具體領(lǐng)域包括但不限于：先導(dǎo)生物活性分子與藥物(小分子與生物制劑)的鑒定、合成與優(yōu)化；藥物發(fā)現(xiàn)背景下新分子實(shí)體的生物學(xué)特性；用于識(shí)別或分析生物活性分子、配體及其目標(biāo)物等的計(jì)算、化學(xué)信息學(xué)和結(jié)構(gòu)研究；新穎和改進(jìn)的方法，包括放射生物化學(xué)，廣泛應(yīng)用于藥物化學(xué)；合成和天然(植物和其他)來(lái)源的生物活性分子的發(fā)現(xiàn)技術(shù)；藥物動(dòng)力學(xué)/藥效學(xué)研究，涉及潛在的藥物處置和反應(yīng)機(jī)制；藥物遺傳學(xué)和藥物基因組學(xué)研究用于加強(qiáng)藥物設(shè)計(jì)和將藥物化學(xué)轉(zhuǎn)化為臨床；藥物代謝機(jī)制與代謝酶基因表達(dá)調(diào)控；與藥物化學(xué)領(lǐng)域相關(guān)的化學(xué)專(zhuān)利。

ACS Medicinal Chemistry Letters is interested in receiving manuscripts that discuss various aspects of medicinal chemistry. The journal will publish studies that pertain to a broad range of subject matter, including compound design and optimization, biological evaluation, drug delivery, imaging agents, and pharmacology of both small and large bioactive molecules. Specific areas include but are not limited to:Identification, synthesis, and optimization of lead biologically active molecules and drugs (small molecules and biologics)Biological characterization of new molecular entities in the context of drug discoveryComputational, cheminformatics, and structural studies for the identification or SAR analysis of bioactive molecules, ligands and their targets, etc.Novel and improved methodologies, including radiation biochemistry, with broad application to medicinal chemistryDiscovery technologies for biologically active molecules from both synthetic and natural (plant and other) sourcesPharmacokinetic/pharmacodynamic studies that address mechanisms underlying drug disposition and responsePharmacogenetic and pharmacogenomic studies used to enhance drug design and the translation of medicinal chemistry into the clinicMechanistic drug metabolism and regulation of metabolic enzyme gene expressionChemistry patents relevant to the medicinal chemistry field